河北快3

三维基因

sanweijiyinzuxue（three-dimensional genomics，3d genomics）, jishizhizaikaolvjiyinzuxulie、jiyinjiegoujiqidiaokongyuanjiandetongshi，duiqizaixibaoheneidesanweikongjianjiegou，jizaijiyinzhuanlu、diaokong、fuzhihexiufudengshengwuguochengzhongdegongnengjinxingyanjiu。 weileyanjiujiyinzudesanweijiegou，meiguojob dekkerjiqihezuozheyu2002nianzuixiankaifachuransezhigouxiangbuhuo（chromatin conformation capture，3c）jishu。3cjishuyongyucedingyizhideliangduanjiyinxulie（dandianyudandian）zhijianshifoucunzaijiaohuzuoyong（xianxingjuliyuandeliangduanxulieyouyukongjianzhedieerbiandebicilinjin）。zhihou，kexuejiamenkuozhanle3cjishu，kaifale4c（circularized chromatin conformation capture）jishu，yongyucedingdandianyuduodianzhijianderansezhijiaohuzuoyong。5c（carbon-copy chromatin conformation capture）jishuyongyucedingduodianyuduodianzhijiandejiaohuzuoyong。weilenengbuhuoquanjiyinzufanweineisuoyouderansezhihuzuoxinxi，job dekkeryanjiutuanduiyu2009niankaifalegaotongliangransetigouxiangbuhuo（high-throughput chromosome conformation capture，hi-c）jishu。ciwai，jiangransetigouxiangbuhuojishuyumianyigongchendianjishuxiangjiehe，renmenkaifalechip-loop、chia-petdengjishu，yongyuyanjiutedingdanbaijiedaodejiyinjianjiaohuzuoyong。