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癌症 炎症与免疫-微环境下的对话

yanzheng,shizhongliudeqidatezhengzhiyi。feikekongxingyanzhengyuzhongliufasheng、fazhanyijiqinxizhuanyimiqiexiangguan。“feikekongxingyanzhengexingzhuanhuadediaokongwangluojiqifenzijizhi”chengwei2016nianduguojiazirankexuejijinzhongdayanjiujihua。yuelaiyueduodezhengjubiaoming,zhongliuxiangguanyanzhengnenggoutongguocujinxueguanxinshenghezhuanyi、dianfukangzhongliumianyiyingdajigaibianzhongliuxibaoduihualiaoyaodeminganxingdengfangmiancujinzhongliudeshengzhanghejinzhan。chixuxingdeyanxingweihuanjingyenengtongguochufajiyintubiancongerdaozhizhongliufasheng。chixucunzaideyanzhengxibaojiyinziyinengjiangzhongliuxiangguanyanxingweihuanjingzhuanhuaweimianyiyizhiweihuanjingcongercujinzhongliujinzhan。 “fuyanzheng(parainflammation)”shiaizhengfashenglingyudezuixinkuozhan。2008nianyeludaxueyixueyuanmianyishengwuxuejiaruslan medzhitovboshizuizaoshiyongfuyanzheng,yimiaoshulilunshangcunzaideyileidishuipingyanzheng。weilejinyibufenxifuyanzhengherenleiaizhengdeguanxi,muqiancongnihaizhengjiyinzukuzhongjinxingshujuwajue,yifaxian18zhongaizheng6523lizhongliucunzaidianxingdedishuipingyanzhengfenzi。qizhongyixianaihebangguangaibilizuigao。 zhongliushengzhangbujinqujueyuexingzhongliuxibaodeyichuangaibian,yequjueyujizhi、xueguan、jinrunyanzhengxibaodengzhongliuweihuanjing(tme,tumor microenvironment)degaibian。zhongliuweihuanjingzhongyoudaliangyanzhengxibaojinrun,baokuofeidaxibao、txibao、suiyuanxingyizhixibao(mdsc)、ziranshashangxibao(nk)、zhongliuxiangguanzhongxinglixibao(tan)hezhongliuxiangguanjushixibao(tam)、zhongliuxiangguanchengxianweixibao(taf)dengduozhongxibaoyaxing,tamenshizhongliuweihuanjingdezhongyaozuchengchengfen,bingfahuilezhongliucujinhuoyizhidezhongyaozuoyong。 lingwai,daliangyanjiuyizhengshizhongliuganxibaoshizhongliunaiyao、fufahezhuanyidegenyuan,manxingyanzhengyuzhongliudefashenghefazhanmiqiexiangguan。zhongliuyanxingweihuanjingzhongdeil-6、il-8、egfdengyanxingyinziheshengzhangyinzijihuolezhongliuganxibaoneinf-κb/stat3xinhaotonglu,weichizhongliuganxibaodeziwogengxinnengli,congercujinzhongliudeshengzhanghezhuanyi。shenruyanjiuzhongliuyanxingweihuanjingduizhongliuganxibaodediaokongjizhi,keyishiwomenzhaodaoqianzaidezhiliaobadian,weigongkezhongliudailaixindesiluheshouduan。 jieci,womenshengwugujubanaizheng, yanzhengyumianyiyantaohui, yaoqingguoneiwaizhuanjia, xuezhe, yishengzuotan, congjichuyanjiujiehelinchuangdejiaoduchufashendujieduaizheng、yanzheng、mianyisanzhexiangguanxing,zhongdiantantaofeikekongxingyanzhengaizhengzhuanhuadeguanxijizhiliaocelve, weizhongliuzhiliaoyulinchuangzhuanhuazhiyinfangxiang。

5 (5次评分)
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  • duiyuchuxuezhefeichanghao.xuexile.xiexielaoshi

    2018-04-30
  • duiyuchuxuezhefeichanghao.xuexile.xiexielaoshi

    2018-04-30
  • duiyuchuxuezhefeichanghao.xuexile.xiexielaoshi

    2018-04-30
  • duiyuchuxuezhefeichanghao.xuexile.xiexielaoshi

    2018-04-30
  • duiyuchuxuezhefeichanghao.xuexile.xiexielaoshi

    2018-04-30
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